[FdaNdcDirectoryPulse](/v/fdandcdirectorypulse) / compare

# BRYTLY vs Cool Buffalo Gel: FdaNdcDirectoryPulse comparison

**BRYTLY (2026-10-16) and Cool Buffalo Gel (2026-10-15) are peer FdaNdcDirectoryPulse records.**

Data as of 2026-11-04 · [Compiled by Zalwin](/research/fdandcdirectorypulse) from U.S. FDA National Drug Code (NDC) Directory via openFDA Copy citation

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## How does BRYTLY compare to Cool Buffalo Gel?

| Field | BRYTLY | Cool Buffalo Gel |
|---|---|---|
| Product | BRYTLY | Cool Buffalo Gel |
| Generic name | Apraclonidine Hydrochloride | Arnica Montana, Calendula Officinalis, Hypericum Perforatum, Bellis Perennis, Calcarea Fluorica, Ferrum Phosphoricum, Ledum Palustre, Natrum Sulphuricum, Rhus Tox, Sulphuricum Acidum, Symphytum Officinale |
| NDC | 0065-8596 | 87758-0001 |
| Labeler | Alcon Laboratories, Inc. | Cool Buffalo, Inc. |
| Product type | HUMAN OTC DRUG | HUMAN OTC DRUG |
| Approval pathway | NDA | UNAPPROVED HOMEOPATHIC |
| Application number | NDA220341 | |
| Dosage form | SOLUTION/ DROPS | GEL |
| Route | OPHTHALMIC | TOPICAL |
| Active ingredients | APRACLONIDINE HYDROCHLORIDE 1.25 mg/mL | ARNICA MONTANA 1 [hp_X]/g; CALENDULA OFFICINALIS FLOWERING TOP 1 [hp_X]/g; HYPERICUM PERFORATUM 1 [hp_X]/g; BELLIS PERENNIS 12 [hp_X]/g; CALCIUM FLUORIDE 30 [hp_X]/g; FERROSOFERRIC PHOSPHATE 30 [hp_X]/g; LEDUM PALUSTRE TWIG 12 [hp_X]/g; SODIUM SULFATE 30 [hp_C]/g |
| Marketing start | 2026-10-16 | 2026-10-15 |
| Package configurations | 3 | 1 |
| Launch Signal Score | 45/100 | 15/100 |
| Peer rank and all 500 records (CSV) | Every comparable record ranked, with amounts, dates and scores 🔒 Click to unlock → |
| Official source URLs for every peer record | Direct links to each record at its government source 🔒 Click to unlock → |

Official records: [BRYTLY](https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=0065-8596) · [Cool Buffalo Gel](https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=87758-0001)

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Listing data comes from the FDA NDC directory via openFDA; a listing is not an FDA approval or endorsement and may be updated or withdrawn. Informational only; not medical advice.

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