# Substances Generally Recognized as Safe

**Action Urgency Score:** 60/100

| Field | Value |
|---|---|
| Agency | Health and Human Services Department; Food and Drug Administration |
| Type | Proposed rule |
| Action | Proposed rule. |
| Published | 2026-08-11 |
| Comments close | 2026-12-09 |
| Significant | Yes (EO 12866) |
| CFR parts | 21 CFR 170, 21 CFR 570 |
| Summary | The Food and Drug Administration (FDA or we) is proposing to require the submission of generally recognized as safe (GRAS) notices for the use of a human or animal food substance purported to be GRAS under the conditions of its intended use under the Federal Food, Drug, and Cosmetic Act (FD&C Act). |
| Document number | 2026-16296 |

## Why this score
- Upcoming deadline.
- Significant rule under EO 12866.

Source: Federal Register API (Office of the Federal Register) (https://www.federalregister.gov/documents/2026/08/11/2026-16296/substances-generally-recognized-as-safe). Last refreshed: 2026-11-04T21:40:49.974Z.
Data from the Federal Register API; the published Federal Register document is authoritative. Informational only, not legal advice.