# Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional) (PAR-27-026)

**Plain-English Eligibility Score:** 80/100

| Field | Value |
|---|---|
| Opportunity number | PAR-27-026 |
| Title | Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional) |
| Agency | National Institutes of Health |
| Status | posted |
| Posted / open date | 2026-06-09 |
| Close date | 2028-09-25 |
| Award ceiling | n/a |
| Award floor | n/a |
| Estimated total funding | n/a |
| Funding category | Health |
| Eligible applicants | City or township governments; Special district governments; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Private institutions of higher education; Small businesses; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Independent school districts; Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; For profit organizations other than small businesses; Native American tribal organizations (other than Federally recognized tribal governments) |
| Eligibility notes | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
| CFDA / Assistance listing | 93.279 |
| Summary | The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder. |
| Agency contact | nidagmbemail@nida.nih.gov |

## Why this score
- Small businesses are listed as eligible applicants.
- Nonprofits are listed as eligible applicants.
- 689 days until the deadline: enough time to prepare a strong application.

Source: Grants.gov (U.S. Department of Health and Human Services) (https://www.grants.gov/search-results-detail/358991). Last refreshed: 2026-11-04T18:11:59.874Z.
Data from Grants.gov. Always read the full notice of funding opportunity before applying. Informational only; not legal or grant-writing advice.