# Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed) (PAR-27-057)

**Plain-English Eligibility Score:** 90/100

| Field | Value |
|---|---|
| Opportunity number | PAR-27-057 |
| Title | Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed) |
| Agency | National Institutes of Health |
| Status | posted |
| Posted / open date | 2026-06-04 |
| Close date | 2029-07-05 |
| Award ceiling | $500,000 |
| Award floor | n/a |
| Estimated total funding | n/a |
| Funding category | Health |
| Eligible applicants | Public and State controlled institutions of higher education; Special district governments; County governments; State governments; Independent school districts; Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Public housing authorities/Indian housing authorities; For profit organizations other than small businesses; Native American tribal governments (Federally recognized); Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments) |
| Eligibility notes | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed. |
| CFDA / Assistance listing | 93.121 |
| Summary | This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encourage |
| Agency contact | deeranotifications@nidcr.nih.gov |

## Why this score
- Small businesses are listed as eligible applicants.
- Nonprofits are listed as eligible applicants.
- 973 days until the deadline: enough time to prepare a strong application.
- Award ceiling of $500,000 suits small organizations.

Source: Grants.gov (U.S. Department of Health and Human Services) (https://www.grants.gov/search-results-detail/360160). Last refreshed: 2026-11-04T18:11:59.874Z.
Data from Grants.gov. Always read the full notice of funding opportunity before applying. Informational only; not legal or grant-writing advice.