# Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed) (PAR-27-081)

**Plain-English Eligibility Score:** 80/100

| Field | Value |
|---|---|
| Opportunity number | PAR-27-081 |
| Title | Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed) |
| Agency | National Institutes of Health |
| Status | posted |
| Posted / open date | 2026-05-04 |
| Close date | 2027-03-05 |
| Award ceiling | n/a |
| Award floor | n/a |
| Estimated total funding | n/a |
| Funding category | Health |
| Eligible applicants | Native American tribal organizations (other than Federally recognized tribal governments); Others (see text field entitled "Additional Information on Eligibility" for clarification); State governments; County governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Independent school districts; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Special district governments; Public housing authorities/Indian housing authorities; Public and State controlled institutions of higher education; City or township governments; Small businesses; For profit organizations other than small businesses; Private institutions of higher education; Native American tribal governments (Federally recognized) |
| Eligibility notes | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
| CFDA / Assistance listing | 93.866, 93.242, 93.867, 93.279 |
| Summary | The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health (NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National  |
| Agency contact | NIA-NOFO-Scientific@nih.gov |

## Why this score
- Small businesses are listed as eligible applicants.
- Nonprofits are listed as eligible applicants.
- 120 days until the deadline: enough time to prepare a strong application.

Source: Grants.gov (U.S. Department of Health and Human Services) (https://www.grants.gov/search-results-detail/360676). Last refreshed: 2026-11-04T18:11:59.874Z.
Data from Grants.gov. Always read the full notice of funding opportunity before applying. Informational only; not legal or grant-writing advice.