# INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) (RFA-OD-27-005)

**Plain-English Eligibility Score:** 80/100

| Field | Value |
|---|---|
| Opportunity number | RFA-OD-27-005 |
| Title | INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required) |
| Agency | National Institutes of Health |
| Status | posted |
| Posted / open date | 2026-05-13 |
| Close date | 2028-06-15 |
| Award ceiling | n/a |
| Award floor | n/a |
| Estimated total funding | $3,000,000 |
| Funding category | Health |
| Eligible applicants | County governments; City or township governments; Special district governments; For profit organizations other than small businesses; Public housing authorities/Indian housing authorities; Native American tribal organizations (other than Federally recognized tribal governments); Independent school districts; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Small businesses; State governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Private institutions of higher education |
| Eligibility notes | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
| CFDA / Assistance listing | 93.395, 93.866, 93.839, 93.838, 93.846, 93.840, 93.173, 93.310, 93.847, 93.837, 93.233, 93.350, 93.865 |
| Summary | The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this NOFO may not exceed five years. This NOFO provides support for up to two years (R61 phase) for preliminar |
| Agency contact | DownSyndromeINCLUDE@mail.nih.gov |

## Why this score
- Small businesses are listed as eligible applicants.
- Nonprofits are listed as eligible applicants.
- 589 days until the deadline: enough time to prepare a strong application.

Source: Grants.gov (U.S. Department of Health and Human Services) (https://www.grants.gov/search-results-detail/360655). Last refreshed: 2026-11-03T18:08:06.385Z.
Data from Grants.gov. Always read the full notice of funding opportunity before applying. Informational only; not legal or grant-writing advice.