# INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed) (RFA-OD-27-003)

**Plain-English Eligibility Score:** 90/100

| Field | Value |
|---|---|
| Opportunity number | RFA-OD-27-003 |
| Title | INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed) |
| Agency | National Institutes of Health |
| Status | posted |
| Posted / open date | 2026-05-12 |
| Close date | 2028-06-15 |
| Award ceiling | $200,000 |
| Award floor | n/a |
| Estimated total funding | $1,000,000 |
| Funding category | Health |
| Eligible applicants | State governments; Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Native American tribal governments (Federally recognized); Independent school districts; For profit organizations other than small businesses; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments); Special district governments; County governments; Others (see text field entitled "Additional Information on Eligibility" for clarification); Private institutions of higher education; Small businesses |
| Eligibility notes | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
| CFDA / Assistance listing | 93.351, 93.865, 93.867, 93.838, 93.866, 93.837, 93.840, 93.839, 93.121, 93.233, 93.846, 93.879, 93.395, 93.173, 93.310, 93.855 |
| Summary | The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an exis |
| Agency contact | DownSyndromeINCLUDE@mail.nih.gov |

## Why this score
- Small businesses are listed as eligible applicants.
- Nonprofits are listed as eligible applicants.
- 589 days until the deadline: enough time to prepare a strong application.
- Award ceiling of $200,000 suits small organizations.

Source: Grants.gov (U.S. Department of Health and Human Services) (https://www.grants.gov/search-results-detail/360653). Last refreshed: 2026-11-03T18:08:06.385Z.
Data from Grants.gov. Always read the full notice of funding opportunity before applying. Informational only; not legal or grant-writing advice.