# INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed) (RFA-OD-27-004)

**Plain-English Eligibility Score:** 90/100

| Field | Value |
|---|---|
| Opportunity number | RFA-OD-27-004 |
| Title | INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed) |
| Agency | National Institutes of Health |
| Status | posted |
| Posted / open date | 2026-05-12 |
| Close date | 2028-06-15 |
| Award ceiling | $500,000 |
| Award floor | n/a |
| Estimated total funding | $3,000,000 |
| Funding category | Health |
| Eligible applicants | Private institutions of higher education; County governments; Small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification); Native American tribal organizations (other than Federally recognized tribal governments); Special district governments; Native American tribal governments (Federally recognized); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; State governments; Public and State controlled institutions of higher education; City or township governments; Public housing authorities/Indian housing authorities |
| Eligibility notes | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
| CFDA / Assistance listing | 93.867, 93.310, 93.846, 93.855, 93.395, 93.847, 93.351, 93.838, 93.866, 93.837, 93.121, 93.233, 93.839, 93.865, 93.879, 93.350, 93.173, 93.242, 93.840 |
| Summary | The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down synd |
| Agency contact | DownSyndromeINCLUDE@mail.nih.gov |

## Why this score
- Small businesses are listed as eligible applicants.
- Nonprofits are listed as eligible applicants.
- 588 days until the deadline: enough time to prepare a strong application.
- Award ceiling of $500,000 suits small organizations.

Source: Grants.gov (U.S. Department of Health and Human Services) (https://www.grants.gov/search-results-detail/360654). Last refreshed: 2026-11-03T18:08:06.385Z.
Data from Grants.gov. Always read the full notice of funding opportunity before applying. Informational only; not legal or grant-writing advice.