# NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) (PA-27-101)

**Plain-English Eligibility Score:** 60/100

| Field | Value |
|---|---|
| Opportunity number | PA-27-101 |
| Title | NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional) |
| Agency | National Institutes of Health |
| Status | posted |
| Posted / open date | 2026-05-28 |
| Close date | 2029-04-05 |
| Award ceiling | n/a |
| Award floor | n/a |
| Estimated total funding | n/a |
| Funding category | Health |
| Eligible applicants | Small businesses |
| Eligibility notes | Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project. This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first si |
| CFDA / Assistance listing | 93.853, 93.838, 93.839, 93.866, 93.307, 93.847, 93.394, 93.837, 93.855, 93.313, 93.393, 93.865, 93.350, 93.242, 93.867, 93.233, 93.351, 93.840, 93.859, 93.273, 93.395 |
| Summary | The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D). |
| Agency contact | SEEDinfo@nih.gov |

## Why this score
- Small businesses are listed as eligible applicants.
- 882 days until the deadline: enough time to prepare a strong application.

Source: Grants.gov (U.S. Department of Health and Human Services) (https://www.grants.gov/search-results-detail/359758). Last refreshed: 2026-11-04T18:11:59.874Z.
Data from Grants.gov. Always read the full notice of funding opportunity before applying. Informational only; not legal or grant-writing advice.